Single‐Molecule Reconstruction of Oligonucleotide Secondary Structure by Atomic Force Microscopy

High resolution AFM enables the first single molecule visualisation of variations in the double helix of DNA.

Pyne A, Thompson R, Leung C, Roy D & Hoogenboom BW (2014) Single-Molecule Reconstruction of Oligonucleotide Secondary Structure by Atomic Force Microscopy. Small 10: 3257–3261
Alice L. B. Pyne, Agnes Noy, Kavit H. S. Main, Victor Velasco-Berrelleza, Michael M. Piperakis, Lesley A. Mitchenall, Fiorella M. Cugliandolo, Joseph G. Beton, Clare E. M. Stevenson, Bart W. Hoogenboom, Andrew D. Bates, Anthony Maxwell & Sarah A. Harris (2021). Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides. Nature Communications, 12(1), 1053.