Publications
Ália dos Santos, Daniel E. Rollins, Yukti Hari-Gupta, Hannah McArthur, Mingxue Du, Sabrina Yong Zi Ru, Kseniia Pidlisna, Ane Stranger, Faeeza Lorgat, Danielle Lambert, Ian Brown, Kevin Howland, Jesse Aaron, Lin Wang, Peter J. I. Ellis, Teng-Leong Chew, Marisa Martin-Fernandez, Alice L. B. Pyne & Christopher P. Toseland.^ 2023 Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription. Nature Communications 14, 2855. DOI:10.1038/s41467-023-38572-9
Beton, J. G., Moorehead, R., Helfmann, L., Gray, R., Hoogenboom, B. W., Praveen Joseph, A., Topf, M. & Pyne, A.L.B.^ 2021 TopoStats – A program for automated tracing of biomolecules from AFM images. Methods 193, 68-79 DOI:10.1016/j.ymeth.2021.01.008
Pyne, A.L.B.*^, Noy, A.*^, Main, K.H.S., Velasco-Berrelleza, V., Piperakis, M.M., Mitchenall, L.A., Cugliandolo, F.M., Beton, J.G., Stevenson, C.E.M., Hoogenboom, B.W., Bates, A.D., Maxwell, A., Harris, S.A.^, 2021. Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides. Nature Communications 12, 1053.DOI: 10.1038/s41467-021-21243-y
Bennett, I., Pyne, A.L.B.^, McKendry, R.A.^, 2020. Cantilever Sensors for Rapid Optical Antimicrobial Sensitivity Testing. ACS Sensors 5, 3133–3139. DOI: 10.1101/679399
Parsons, E.S., Stanley, G.J., Pyne, A.L.B., Hodel, A.W., Nievergelt, A.P., Menny, A., Yon, A.R., Rowley, A., Richter, R.P., Fantner, G.E., Bubeck, D., Hoogenboom, B.W., 2019. Single-molecule kinetics of pore assembly by the membrane attack complex. Nature Communications 10, 2066. DOI: 10.1038/s41467-019-10058-7
Akpinar, B., Haynes, P.J., Bell, N.A.W., Brunner, K., Pyne, A.L.B.^, Hoogenboom, B.W.^, 2019. PEGylated surfaces for the study of DNA–protein interactions by atomic force microscopy. Nanoscale 11, 20072–20080. DOI: 10.1039/C9NR07104K
Benn, G., Pyne, A.L.B., Ryadnov, M.G., Hoogenboom, B.W., 2019. Imaging live bacteria at the nanoscale: comparison of immobilisation strategies. Analyst 144, 6944–6952. DOI: 10.1039/C9AN01185D
Heesterbeek, D.A., Bardoel, B.W., Parsons, E.S., Bennett, I., Ruyken, M., Doorduijn, D.J., Gorham, R.D., Berends, E.T., Pyne, A.L.B., Hoogenboom, B.W., Rooijakkers, S.H., 2019. Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases. The EMBO Journal 38, e99852. DOI: 10.15252/embj.201899852
Pfeil, M.-P.*, Pyne, A.L.B.*, Losasso, V., Ravi, J., Lamarre, B., Faruqui, N., Alkassem, H., Hammond, K., Judge, P.J., Winn, M., Martyna, G.J., Crain, J., Watts, A., Hoogenboom, B.W., Ryadnov, M.G., 2018. Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms. Scientific Reports 8, 14926. DOI: 10.1038/s41598-018-33289-y
Burns, J.R., Lamarre, B., Pyne, A.L.B., Noble, J.E., Ryadnov, M.G., 2018. DNA Origami Inside-Out Viruses. ACS Synthetic Biology 7, 767–773. DOI: 10.1021/acssynbio.7b00278
Pyne, A.*, Pfeil, M.-P.*, Bennett, I., Ravi, J., Iavicoli, P., Lamarre, B., Roethke, A., Ray, S., Jiang, H., Bella, A., Reisinger, B., Yin, D., Little, B., Muñoz-García, J.C., Cerasoli, E., Judge, P.J., Faruqui, N., Calzolai, L., Henrion, A., Martyna, G.J., Grovenor, C.R.M., Crain, J., Hoogenboom, B.W., Watts, A., Ryadnov, M.G., 2017. Engineering monolayer poration for rapid exfoliation of microbial membranes. Chemical Science 8, 1105–1115. DOI: 10.1039/C6SC02925F
Klejevskaja, B.*, Pyne, A.L.B.*, Reynolds, M.*, Shivalingam, A., Thorogate, R., Hoogenboom, B.W., Ying, L., Vilar, R., 2016. Studies of G-quadruplexes formed within self-assembled DNA mini-circles. Chemical Communications 52, 12454–12457. DOI: 10.1039/C6CC07110D
Messager, L., Burns, J.R., Kim, J., Cecchin, D., Hindley, J., Pyne, A.L.B., Gaitzsch, J., Battaglia, G., Howorka, S., 2016. Biomimetic Hybrid Nanocontainers with Selective Permeability. Angewandte Chemie 128, 11272–11275. DOI: 10.1002/ange.201604677
Pyne, A.L.B., Hoogenboom, B.W., 2016. Imaging DNA Structure by Atomic Force Microscopy, in: Leake, M.C. (Ed.), Chromosome Architecture. Springer New York, New York, NY, pp. 47–60. DOI: 10.1007/978-1-4939-3631-1_5
Pyne, A., Thompson, R., Leung, C., Roy, D., Hoogenboom, B.W., 2014. Single-Molecule Reconstruction of Oligonucleotide Secondary Structure by Atomic Force Microscopy. Small 10, 3257–3261. DOI: 10.1002/smll.201400265
Rakowska, P.D.*, Jiang, H.*, Ray, S.*, Pyne, A., Lamarre, B., Carr, M., Judge, P.J., Ravi, J., Gerling, U.I.M., Koksch, B., Martyna, G.J., Hoogenboom, B.W., Watts, A., Crain, J., Grovenor, C.R.M., Ryadnov, M.G., 2013. Nanoscale imaging reveals laterally expanding antimicrobial pores in lipid bilayers. Proceedings of the National Academy of Sciences of the United States of America 110, 8918–8923. DOI: 10.1073/pnas.1222824110
Leung, C., Bestembayeva, A., Thorogate, R., Stinson, J., Pyne, A., Marcovich, C., Yang, J.L., Drechsler, U., Despont, M., Jankowski, T., 2012. Atomic Force Microscopy with Nanoscale Cantilevers Resolves Different Structural Conformations of the DNA Double Helix. Nano letters 12, 3846–3850. DOI: 10.1021/nl301857p
Pyne, A.*, Marks, W.*, Picco, L., Dunton, P., Ulcinas, A., E Barbour, M., Jones, S., Gimzewski, J.K., Miles, M.J., 2009. High-speed atomic force microscopy of dental enamel dissolution in citric acid. Archives of Histology and Cytology 72, 209–215. DOI: 10.1679/aohc.72.209
* authors contributed equally to this work
^ corresponding author(s)