Investigating DNA interactions through single-molecule Atomic Force Microscopy

DNA interactions underpin some of the most fundamental process in living cells, including DNA repair and replication. Using high resolution single-molecule AFM we are able to quantify strutural changes induced by binding of external factors such as DNA and proteins. We hope to use this information to uncover mechanisms underlying fundamental cellular processes, from genome organisation to targeted drug development. You can find out more here about the methods we use to image DNA-Protein interactions

This cluster is led by Dr. Harriet Read, please get in contact if you would like to know more.