Guest User
Paper published showing the helix of ‘dancing ...
Paper published showing the helix of ‘dancing DNA’
Guest User
Isabel and Alice publish paper on a new way to ...
Isabel and Alice publish paper on a new way to detect antimicrobial resistance
Alice Pyne
Caught in the act - catching the membrane ...

Our immune system relies on nanomachines, such as the membrane attack complex (MAC) to kill invasive bacteria in our blood. Our research, published in the EMBO journal and Nature Communications, provides us with a better understanding of how the immune system kills bacteria. This may guide the development of new therapies that harness the immune system against bacterial infections, and strategies that repurpose the immune system to act against other rogue cells in the body.

Caught in the act - catching the membrane attack complex on camera
Alice Pyne
Our DNA research is featured in Forbes Magazine

For #DNADay19 Eva Amsen has written an article discussing what how we can ‘see’ DNA, and what we can learn about its structure from ‘seeing’ it.

You can read the article here

Our DNA research is featured in Forbes Magazine
Antimicrobial peptides
Alice Pyne
Paper published: creating new antibiotics from ...

New antibiotics are desperately needed: without them antimicrobial resistance is predicted to kill more people than cancer. An international collaboration between scientists at the London Centre for Nanotechnology (LCN), University of Oxford, IBM, STFC Daresbury Laboratory and the National Physical Laboratory (NPL) has shown that our own bodies may provide an answer.

Paper published: creating new antibiotics from our own immune system

A new chapter - Alice moves to the University of Sheffield to take up a lectureship in the Department of Materials Science

After almost a decade, Alice is leaving UCL to take up a position at the University of Sheffield in the Department of Materials Science and Engineering.

I am really excited to start a new chapter in my research, continuing on with all of my current collaborators, but also to find new collaborators, both in Engineering and Materials Science, and throughout the University of Sheffield. This should be made a little easier by the growing DNA presence at the University of Sheffield, which I encountered at #NAF2019, and whom I hope to meet more of through SInFoNiA.

I can’t wait to get started, and to meet my new colleagues. I’d also like to thank everyone at UCL who’s contributed to my journey there, its been an incredible place to learn and work. I look forward to visiting, I will have an honorary position there, so will be back often!

 

The Robert Hadfield Building, University of Sheffield

The 15th Nucleic Acids Forum #NAF2019

The 15th Nucleic Acids Forum #NAF2019

NAF 2019 was a brilliant meeting, organised by David Rueda, at the Royal Society of Chemistry. There were a series of brilliant talks, with an engaged and interested audience. Alice’s talk on supercoiling in DNA minicircles - ‘Untangling DNA, one molecule at a time’ - was well received, and she was awarded a model of the structure of the BDNA double helix, fabricated by Molecular Models. Thanks to the Nucleic Acids Group, David Rueda and his lab for organising an inspiring day of talks. We’re already looking forward to next year!

Caught in the act - catching the membrane attack complex on camera

Caught in the act - catching the membrane attack complex on camera

Our immune system relies on nanomachines, such as the membrane attack complex (MAC) to kill invasive bacteria in our blood. Our research, published in the EMBO journal and Nature Communications, provides us with a better understanding of how the immune system kills bacteria. This may guide the development of new therapies that harness the immune system against bacterial infections, and strategies that repurpose the immune system to act against other rogue cells in the body.

Untangling DNA - one molecule at a time at BIRS: The Topology of Nucleic Acids

Untangling DNA - one molecule at a time at BIRS: The Topology of Nucleic Acids

Alice is visiting the Banff International Research Station (BIRS) in Banff, Alberta to present our work on DNA topology at The Topology of Nucleic Acids: Research at the Interface of Low-Dimensional Topology, Polymer Physics and Molecular Biology.

If you’d like to see the talk, you can watch it here.

'Targeting Twist' at the Physics of Life PolNET2 2018 Symposium

'Targeting Twist' at the Physics of Life PolNET2 2018 Symposium

On the 10th December 2018, Kavit attended the ‘Physics of Life PoLNET2 2018 Symposium: Molecules, Mechanics, Medicine and More!’ at the University of York. The interdisciplinary symposium aimed to showcase collaborative projects across Biology and Physics with discussions ranging from evolution to epigenetics.

Paper published: creating new antibiotics from our own immune system

Paper published: creating new antibiotics from our own immune system

New antibiotics are desperately needed: without them antimicrobial resistance is predicted to kill more people than cancer. An international collaboration between scientists at the London Centre for Nanotechnology (LCN), University of Oxford, IBM, STFC Daresbury Laboratory and the National Physical Laboratory (NPL) has shown that our own bodies may provide an answer.

Kavit Main has joined the group to carry out his MSc research project

Kavit Main has joined the group to carry out his MSc research project

Kavit Main has joined the group to carry out a research project for his MSc in Cancer at the UCL Cancer Institute. His project aims to use Atomic Force Microscopy to gain single-molecule insights into supercoiled DNA-topoisomerase interactions.

Aside from academia, Kavit practises Nasta’liq and Devanagari calligraphy, Mughal miniature painting and enjoys Urdu poetry and hiking.