Our group’s latest research on “Quantifying complexity in DNA structures with high resolution Atomic Force Microscopy“ has been published in Nature Communications. In this work, we present a novel approach for automated tracing of complex DNA molecules from AFM images, showcasing how this enables detailed quantification of individual DNA conformations and accurate classification of their topological states. The paper was an exciting collaboration between experimental and computational members of the Pyne lab, as well as Dr. James Provan and Prof. Sean Colloms (University of Glasgow), Dr. Renáta Rusková and Dr. Dušan Račko (Polymer Institute of the Slovak Academy of Sciences), and Dr. Neville S. Gilhooly and Prof. Agnieszka Gambus (University of Birmingham). You can read the full paper here!
The timing of the paper’s acceptance was especially meaningful, coinciding with first authors Dr. Elizabeth Holmes and Dr. Max Gamill’s PhD vivas… a well-earned highlight they were proud to share with their examiners!
