James Provan, from Sean Colloms’ lab at the University of Glasgow, visited our lab for a month, to carry out high resolution AFM imaging of DNA, kindly funded by the Microbiology Society. James wrote a blog post about his visit, which you can access by clicking on the title!
Isabel passes her viva! Congratulations Dr Bennett
Congratulations to Dr Bennett on passing (and enjoying) her viva, and thank you to her brilliant examiners, Til Bachmann and Carmel Curtis for making it such a great experience. Its been an absolute pleasure working with Isabel for the past 5 years - I’m excited to see what the future has in store for you.
A new chapter - Alice moves to the University of Sheffield to take up a lectureship in the Department of Materials Science
After almost a decade, Alice is leaving UCL to take up a position at the University of Sheffield in the Department of Materials Science and Engineering.
I am really excited to start a new chapter in my research, continuing on with all of my current collaborators, but also to find new collaborators, both in Engineering and Materials Science, and throughout the University of Sheffield. This should be made a little easier by the growing DNA presence at the University of Sheffield, which I encountered at #NAF2019, and whom I hope to meet more of through SInFoNiA.
I can’t wait to get started, and to meet my new colleagues. I’d also like to thank everyone at UCL who’s contributed to my journey there, its been an incredible place to learn and work. I look forward to visiting, I will have an honorary position there, so will be back often!
The Robert Hadfield Building, University of Sheffield
The 15th Nucleic Acids Forum #NAF2019
NAF 2019 was a brilliant meeting, organised by David Rueda, at the Royal Society of Chemistry. There were a series of brilliant talks, with an engaged and interested audience. Alice’s talk on supercoiling in DNA minicircles - ‘Untangling DNA, one molecule at a time’ - was well received, and she was awarded a model of the structure of the BDNA double helix, fabricated by Molecular Models. Thanks to the Nucleic Acids Group, David Rueda and his lab for organising an inspiring day of talks. We’re already looking forward to next year!
MMC 2019
MMC2019 was a very proud moment for me, to watch my first PhD student Kavit Main, give an absolutely outstanding talk, the day after his graduation, and present an engaging clear, and stunning talk. Well done Kavit!
Sell-out talk at Pint of Science #pint19
Alice gave a sold out out talk at London’s ‘Atoms to Galaxies’ Pint of Science event. If you missed it, the abstract is here
Caught in the act - catching the membrane attack complex on camera
Our immune system relies on nanomachines, such as the membrane attack complex (MAC) to kill invasive bacteria in our blood. Our research, published in the EMBO journal and Nature Communications, provides us with a better understanding of how the immune system kills bacteria. This may guide the development of new therapies that harness the immune system against bacterial infections, and strategies that repurpose the immune system to act against other rogue cells in the body.
Paper Published in Nature Communications: Capturing the Membrane Attack Complex on Camera
Our DNA research is featured in Forbes Magazine
Untangling DNA - one molecule at a time at BIRS: The Topology of Nucleic Acids
Alice is visiting the Banff International Research Station (BIRS) in Banff, Alberta to present our work on DNA topology at The Topology of Nucleic Acids: Research at the Interface of Low-Dimensional Topology, Polymer Physics and Molecular Biology.
If you’d like to see the talk, you can watch it here.
ACS Synthetic Biology Cover highlight
The cover of the newly released (March 2018) ACS Synthetic Biology highlights our exciting collaborative research with UCL Chemistry and The National Physical Laboratory
New paper published in EMBO: Deciphering the mechanism of action of the membrane attack complex (MAC)
'Targeting Twist' at the Physics of Life PolNET2 2018 Symposium
On the 10th December 2018, Kavit attended the ‘Physics of Life PoLNET2 2018 Symposium: Molecules, Mechanics, Medicine and More!’ at the University of York. The interdisciplinary symposium aimed to showcase collaborative projects across Biology and Physics with discussions ranging from evolution to epigenetics.
Paper published: creating new antibiotics from our own immune system
New antibiotics are desperately needed: without them antimicrobial resistance is predicted to kill more people than cancer. An international collaboration between scientists at the London Centre for Nanotechnology (LCN), University of Oxford, IBM, STFC Daresbury Laboratory and the National Physical Laboratory (NPL) has shown that our own bodies may provide an answer.
New paper published: Creating new antibiotics from our own immune system
New antibiotics are desperately needed: without them antimicrobial resistance is predicted to kill more people than cancer. An international collaboration between scientists at the London Centre for Nanotechnology (LCN), University of Oxford, IBM, STFC Daresbury Laboratory and the National Physical Laboratory (NPL) has shown that our own bodies may provide an answer.
Kavit Main has joined the group to carry out his MSc research project
Kavit Main has joined the group to carry out a research project for his MSc in Cancer at the UCL Cancer Institute. His project aims to use Atomic Force Microscopy to gain single-molecule insights into supercoiled DNA-topoisomerase interactions.
Aside from academia, Kavit practises Nasta’liq and Devanagari calligraphy, Mughal miniature painting and enjoys Urdu poetry and hiking.
Mimicking viruses from inside out using DNA origami
The cover of the current issue of ACS Synthetic Biology highlights the our collaborative research project with UCL Chemistry and the National Physical Laboratory to engineer a programmable inside-out “virus”. This everted “virus” is designed to deliver functional proteins into live cells.
New paper published in ACS Synthetic Biology (February 2018)
DNA Origami Inside-Out Virus
Alice has been awarded a prestigious MRC/UKRI Innovation Fellowship (Jan 2018)
This exciting new fellowship aims to create the future for international leaders in research.











